PFAS exposure can cause ulcerative colitis by disrupting immune regulation, causing damage to intestinal lining integrity, and altering gut microbiota, particularly in individuals who consume contaminated water sources and those who have regular occupational exposure.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting veterans significantly. The VA offers disability ratings for UC, ranging from 10% to 100%, based on severity and daily impact. Key causes include genetic factors, immune system dysfunction, environmental toxins like PFAS chemicals, and lifestyle factors. Symptoms include severe diarrhea, abdominal pain, and weight loss. Veterans seeking benefits must provide comprehensive medical evidence, submit a claim, and undergo a C&P exam. Understanding these ratings and the application process can help veterans manage their condition and improve their quality of life.